(S01E01) "Shut up. I don't like chatty. I don't do chatty. I like quiet." - Nurse Jackie to young nurse Zoey
It's hard not to think of Edie Falco as Carmela Soprano, because she's so identified with the role. But I have a feeling that after a few episodes of Nurse Jackie, Carmela will fade a bit in our minds and Jackie will start to take over. She's a complex character who snorts painkillers, has sex with the hospital druggist, looks after patients with a vengeance, tells doctors off, and goes home each night to a loving husband and two kids. She's one hot mess.
Seriously, they had me with the opening song, "Theme from Valley of the Dolls," sung by one of my favorite singers in the world, Dionne Warwick. They couldn't have picked a better song to start this series. Like the three women in that movie, Jackie is on a mission, but gets messed up in the process.
Remember that 
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